General
Preferred name
torin 1
Synonyms
JW-7-52-1 ()
TORIN1 ()
P&D ID
PD012797
CAS
1222998-36-8
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
calculated probe
experimental probe
P&D approved
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
224
No orthogonal probes found
Similar probes
3
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Torin 1 is a potent inhibitor of mTOR in both mTOR containing protein complexes, mTORC1 and mTORC2. The discovery of torin 1 is described in , where it is compound 37.
(GtoPdb)
PRICE
109
DESCRIPTION
Potent and selective mTOR inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
339
Organisms
0
Compound Sets
26
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
Gray Laboratory Probes
Guide to Pharmacology
High-quality chemical probes
LINCS compound set
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Welcome Trust Cancer Drugs
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
607.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
7
Aromatic Ring Count
6
cLogP
6.83
TPSA
71.33
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
TOR signaling
Autophagy
DNA Damage/DNA Repair
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Target
MTOR
p110¦Ã
Autophagy,mTOR
DNA-PK
mTORC1
mTORC2
p110γ
Primary Target
mTOR
MOA
DNA-PK inhibitor
PI3K inhibitor
Inhibitor
mTOR inhibitor
Recommended Cell Concentration
100 nM
Source data
